Several weeks ago, a long-term psoriasis patient of mine came to me with completely clear skin. He noticed that his skin had cleared dramatically when he received a B-12 shot two or three months before his visit. The question is: does B-12 have any role in the treatment of psoriasis? After reviewing the role of B-12, reading about B-12 with respect to psoriasis, there was one study done in the 1960’s. The research was a small randomized trial, which showed no efficacy of B-12 and psoriasis.